图 书 馆
蛋白质 - 蛋白质网络中基于协作相互作用的功能预测Collaboration-based function prediction in protein-protein interaction networks |
|
| 课程网址: | http://videolectures.net/mlsb2010_rahmani_cbf/ |
| 主讲教师: | Hossein Rahmani |
| 开课单位: | 莱顿大学 |
| 开课时间: | 2010-11-08 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | We consider the problem of predicting the functions of individual proteins in protein-protein interaction (PPI) networks. Existing techniques assume that proteins that are topologically close in the network tend to have similar functions. We hypothesize that better predictive accuracy can be obtained by generalizing this assumption. We call two functions collaborative if proteins with one function often interact with proteins performing the other function. Our hypothesis is that techniques that extract such function collaboration information from networks, and exploit it, can yield better predictions.We propose and evaluate two such techniques. A comparative evaluation on three S. cerevisiae interaction networks, at different levels of detail, shows that the new techniques consistently improve over state of the art function prediction techniques, with improvements in F-measure ranging from 3% to 17%. |
| 关 键 词: | 蛋白质; 相互作用; 比较评价 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-07-02：cwx |
| 阅读次数: | 86 |