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积极学习酶的功能Active and guided learning of enzyme function |
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| 课程网址: | http://videolectures.net/mlsb2012_ferrari_active/ |
| 主讲教师: | Luna De Ferrari |
| 开课单位: | 圣安德鲁斯大学 |
| 开课时间: | 2012-10-23 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Manual annotation cannot keep up with enzyme sequence discovery. In this work, we modelled the use of active and guided learning to support enzyme function curation. We evaluated, on 5,750 E. coli proteins, nine strategies to sort instances for curation. We found that selecting sets of InterPro features in order of frequency of occurrence can cut the curation effort by almost two thirds, while maintaining very high accuracy and recall. The method can be applied to real-life datasets of millions of proteins thanks to its limited computational requirements, parallelisation, good coverage of rare classes and flexibility in selecting instances for annotation. |
| 关 键 词: | 酶序列; 蛋白质; 策展工作 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-07-03：cwx |
| 阅读次数: | 78 |