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解读转录调控：从个体位点到细胞类型特异性表达Deciphering transcription regulation: from individual sites to cell type specific expression |
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| 课程网址: | http://videolectures.net/mlsb2012_ohler_transcription/ |
| 主讲教师: | Uwe Ohler |
| 开课单位: | 杜克大学 |
| 开课时间: | 2012-10-23 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Understanding how transcription regulation is encoded in the genomes of complex multicellular organisms has been a big challenge, not least due to the large non-coding space where relevant interactions might occur. High throughput technologies now allow it to map putative regulatory regions via their chromatin structure, and have made rapid progress in identifying in vivo binding of transcription factors to DNA at high resolution. Large collections of relevant data have been made available by individual groups as well as large consortia such as mod/ENCODE. I will discuss some of our recent and ongoing efforts that make use of such datasets to define successful computational models for individual sites as well as for cell-type specific expression. |
| 关 键 词: | 转录调控; 基因组; 特异性表达 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-07-09：cjy |
| 阅读次数: | 56 |