图 书 馆
基于隔室特异性生物学特征的蛋白质亚细胞定位预测Protein Subcellular Localization Prediction Based on Compartment-Specific Biological Features |
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| 课程网址: | http://videolectures.net/mlss06tw_su_pslpb/ |
| 主讲教师: | Chia-Yu Su |
| 开课单位: | 信息科学研究所 |
| 开课时间: | 2007-02-25 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Prediction of subcellular localization of proteins is important for genome annotation, protein function prediction, and drug discovery. We present a prediction method for Gram-negative bacteria that uses ten one-versus-one support vector machine (SVM) classifiers, where compartment-specific biological features are selected as input to each SVM classifier. The final prediction of localization sites is determined by inte-grating the results from ten binary classifiers using a combination of majority votes and a probabilistic method. The overall accuracy reaches 91.4%, which is 1.6% better than the state-of-the-art system, in a ten-fold cross-validation evaluation on a bench-mark data set. We demonstrate that feature selection guided by biological knowledge and insights in one-versus-one SVM classifiers can lead to a significant improvement in the prediction performance. Our model is also used to produce highly accurate prediction of 92.8% overall accuracy for proteins of dual localizations. |
| 关 键 词: | 亚细胞定位; 革兰氏阴性细菌; 蛋白质功能预测 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-08-09：cjy |
| 阅读次数: | 42 |