图 书 馆
定向物理网络Orienting physical networks |
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| 课程网址: | http://videolectures.net/nipsworkshops2010_sharan_opn/ |
| 主讲教师: | Roded Sharan |
| 开课单位: | 特拉维夫大学 |
| 开课时间: | 2011-01-13 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | In a network orientation problem one is given a mixed graph, consisting of directed and undirected edges, and a set of sourcetarget vertex pairs. The goal is to orient the undirected edges so that a maximum number of pairs admit a directed path from the source to the target. This problem arises in the context of analyzing physical networks of protein-protein and protein- DNA interactions. While the latter are naturally directed from a transcription factor to a gene, the direction of signal flow in protein-protein interactions is often unknown or cannot even be measured en masse. One then tries to infer this information by using causality data on pairs of genes such that the perturbation of one gene changes the expression level of the other gene. In my talk I will discuss the complexity of the problem, show approximation algorithms for several variants of it and present an efficient ILP solution for it. I will then describe the application of this algorithm to orient protein-protein interactions in yeast, improving our understanding of the structure and function of the network. |
| 关 键 词: | 网络方向; 混合图; 蛋白质 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-09-07：lxf |
| 阅读次数: | 60 |