图 书 馆
从多个衰老相关表型推断生理年龄Inferring a measure of physiological age from multiple ageing related phenotypes |
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| 课程网址: | http://videolectures.net/nipsworkshops2011_knowles_phenotypes/ |
| 主讲教师: | David Knowles |
| 开课单位: | 剑桥大学 |
| 开课时间: | 2012-01-23 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | What is ageing? One definition is simultaneous degradation of multiple organ systems. Can an individual be said to be “old” or “young” for their (chronological) age in a scientifically meaningful way? We investigate these questions using ageing related phenotypes measured on the 12,000 female twins in the Twins UK study. We propose a simple linear model of ageing, which allows a latent adjustment delta to be made to an individual’s chronological age to give their “physiological age”, shared across the observed phenotypes. We note problems with the analysis resulting from the linearity assumption and show how to alleviate these issues using a non-linear extension. We find more gene expression probes are significantly associated with our measurement of physiological age than to chronological age. |
| 关 键 词: | 多器官系统; 老化线性模型; 非线性扩展 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-09-07：lxf |
| 阅读次数: | 49 |