检测人体和模型生物体对实验因素的类似高维反应Detecting similar high-dimensional responses to experimental factors from human and model organism |
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课程网址: | http://videolectures.net/nipsworkshops2011_suvitaival_organism/ |
主讲教师: | Tommi Suvitaival |
开课单位: | 阿尔托大学 |
开课时间: | 2012-01-23 |
课程语种: | 英语 |
中文简介: | 我们提出了一个贝叶斯模型,用于分析多个实验因素在两个物种研究中的效果,而不需要先验已知的匹配。从人类疾病的模型研究,使用*组学技术和各种模式生物进行,问题出现了:是否有类似的东西在某些条件下,不同生物的分子反应,如健康与患病?我们的方法为分析多物种数据的任务提供了生成模型,自然地考虑了关于性别,年龄,治疗或疾病状态等影响因素的额外信息。 |
课程简介: | We present a Bayesian model for analysing the effect of multiple experimental factors in two-species studies without the requirement of a priori known matching. From model studies of human diseases, conducted using *omics technologies and various model organisms, the question emerges: is there something similar in the molecular responses of the different organisms under certain conditions, such as healthy vs. diseased? Our approach provides a generative model for the task of analysing multi-species data, naturally taking into account the additional information about the affecting factors such as gender, age, treatment, or disease status. |
关 键 词: | 贝叶斯模型; 分子反应; 生成模型 |
课程来源: | 视频讲座网 |
最后编审: | 2019-09-07:lxf |
阅读次数: | 32 |