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用高斯过程模拟转录调控Modelling Transcriptional Regulation with Gaussian Processes |
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| 课程网址: | http://videolectures.net/pesb07_lawrence_mtr/ |
| 主讲教师: | Neil D. Lawrence |
| 开课单位: | 谢菲尔德大学 |
| 开课时间: | 2007-04-04 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Modelling the dynamics of transcriptional processes in the cell requires the knowledge of a number of key biological quantities. While some of them are relatively easy to measure, such as mRNA decay rates and mRNA abundance levels, it is still very hard to measure the active concentration levels of the transcription factor proteins that drive the process and the sensitivity of target genes to these concentrations. In this paper we show how these quantities for a given transcription factor can be inferred from gene expression levels of a set of known target genes. We treat the protein concentration as a latent function with a Gaussian process prior, and include the sensitivities, mRNA decay rates and baseline expression levels as hyperparameters. We apply this procedure to a human leukemia dataset, focusing on the tumour repressor p53 and obtaining results in good accordance with recent biological studies. Joint work with Guido Sanguinetti and Magnus Rattray. |
| 关 键 词: | 模拟细胞; 转录因子; 靶基因 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2020-01-13：chenxin |
| 阅读次数: | 52 |