图 书 馆
转录调控模型的最小二乘估计Least squares estimation of a transcription regulation model |
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| 课程网址: | http://videolectures.net/pmnp07_niranjan_lse/ |
| 主讲教师: | Mahesan Niranjan |
| 开课单位: | 谢菲尔德大学 |
| 开课时间: | 2007-09-05 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | The way transcription factors regulate the activity of their target genes is of much interest. Several authors have recently used model based computational approaches to infer concentrations of transcription factor proteins from high throughput gene expression data ([1-3,6-7]. Here, I present an approach explicitly formulated to model periodic biological phenomena, and a least squares framework for parameter estimation of such a model. Such a computational strategy can be used to infer levels of transcription factor activities at the protein level using genes that are regulated by single transcription factors, and then to decipher “transcriptional logic” of genes under regulation by the comboined actions of multiple transcription factors. |
| 关 键 词: | 转录因子; 靶基因; 最小二乘框架 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2020-01-13：chenxin |
| 阅读次数: | 56 |