图 书 馆
SlimSearch：一个结合序列上下文的网络服务器，用于在蛋白质中发现新的短线性基序SLiMSearch: A Webserver for Finding Novel Occurrences of Short Linear Motifs in Proteins, Incorporating Sequence Context |
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| 课程网址: | http://videolectures.net/prib2010_edwards_swfn/ |
| 主讲教师: | Richard J. Edwards |
| 开课单位: | 南安普敦大学 |
| 开课时间: | 2010-10-14 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Short, linear motifs (SLiMs) play a critical role in many biological processes. The SLiMSearch (Short, Linear Motif Search) webserver is a flexible tool that enables researchers to identify novel occurrences of pre-defined SLiMs in sets of proteins. Numerous masking options give the user great control over the contextual information to be included in the analyses, including evolutionary filtering and protein structural disorder. User-friendly output and visualizations of motif context allow the user to quickly gain insight into the validity of a putatively functional motif occurrence. Users can search motifs against the human proteome, or submit their own datasets of UniProt proteins, in which case motif support within the dataset is statistically assessed for over- and under-representation, accounting for evolutionary relationships between input proteins. SLiMSearch is freely available as open source Python modules and all webserver results are available for download. |
| 关 键 词: | 短线性图案; 蛋白质组; 进化过滤 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2021-12-21：liyy |
| 阅读次数: | 83 |