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蛋白质表面比较方法及其在结合位点识别中的应用

Methods for Comparing Protein Surfaces and their Application to Binding Site Recognition
课程网址: http://videolectures.net/prib2010_guerra_mcps/  
主讲教师: Concettina Guerra
开课单位: 帕多瓦大学
开课时间: 2010-10-14
课程语种: 英语
中文简介:
在两个蛋白质表面上发现相似区域可以导致关于该区域对于一种蛋白质的功能作用或分子相互作用的重要推断,如果这些信息可用于另一种蛋白质的话。本教程将介绍蛋白质蛋白质相互作用的基本原理,并回顾最近比较蛋白质表面和识别结合位点的方法。它将侧重于蛋白质表面比较问题的几何方面。涵盖的主题包括表面表示的局部形状描述符;蛋白质建模的基本数据结构;相似度量;主题发现蛋白质的功能注释;在计算机视觉领域开发的方法应用于蛋白质结构比较中的问题。
课程简介: Discovery of a similar region on two protein surfaces can lead to important inference about the functional role or molecular interaction of this region for one of the proteins if such information is available for the other. This tutorial will present the basic principles of protein-protein interactions and review recent approaches to compare protein surfaces and to recognize binding sites. It will focus on the geometric aspects of the protein surface comparison problem. Topics covered include local shape descriptors for the representations of the surfaces; basic data structures for modelling proteins; similarity measures; motif finding for the functional annotation of proteins; application of methods developed in the area of computer vision to problems in protein structure comparison.
关 键 词: 蛋白质; 分子相互作用; 计算机视觉
课程来源: 视频讲座网
最后编审: 2019-09-14:lxf
阅读次数: 64