图 书 馆
人群拷贝数多态性识别与基因分型的优化算法Optimization Algorithms for Identification and Genotyping of Copy Number Polymorphisms in Human Populations |
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| 课程网址: | http://videolectures.net/prib2010_ruffalo_oaig/ |
| 主讲教师: | Matthew Ruffalo |
| 开课单位: | 凯斯西储大学 |
| 开课时间: | 2010-10-14 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Recent studies show that copy number polymorphisms (CNPs), defined as genome segments that are polymorphic with regard to genomic copy number and segregate at greater than 1% frequency in the populations, are associated with various diseases. Since rare copy number variations (CNVs) and CNPs bear different characteristics, the problem of discovering CNPs presents opportunities beyond what is available to algorithms that are designed to identify rare CNVs. We present a method for identifying and genotyping common CNPs. The proposed method, POLYGON, produces copy number genotypes of the samples at each CNP and fine-tunes its boundaries by framing CNP identification and genotyping as an optimization problem with an explicitly formulated objective function. We apply POLYGON to data from hundreds of samples and demonstrate that it significantly improves the performance of existing single-sample CNV identification methods. We also demonstrate its superior performance as compared to two other CNP identification/genotyping methods. |
| 关 键 词: | 基因组片段; 拷贝数变异; 目标函数 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-09-14：lxf |
| 阅读次数: | 70 |