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形态发生的自组织原理Self-organizing principles in branching morphogenesis |
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| 课程网址: | http://videolectures.net/kolokviji_hannezo_branching_morphogenesi... |
| 主讲教师: | Edouard Hannezo |
| 开课单位: | 奥地利科学技术学院 |
| 开课时间: | 2018-05-28 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | The morphogenesis of branched organs remains a subject of abiding interest. Although much is known about the underlying signaling pathways, it remains unclear how macro-scopic features of branched organs, including their size, network topology, and spatial patterning, are encoded. Here, we show that, in mouse mammary gland, kidney, and hu-man prostate, these features can be explained quantitatively within a single unifying framework of branching and annihilating random walks. Based on quantitative analyses of large-scale organ reconstructions and proliferation kinetics measurements, we propose that morphogenesis follows from the proliferative activity of equipotent tips that stochas-tically branch and randomly explore their environment but compete neutrally for space, becoming proliferatively inactive when in proximity with neighboring ducts. These results show that complex branched epithelial structures develop as a self-organized process, reliant upon a strikingly simple but generic rule, without recourse to a rigid and determin-istic sequence of genetically programmed events. |
| 关 键 词: | 器官; 组织; 增殖活动 |
| 课程来源: | 视频讲座网 |
| 数据采集: | 2020-11-09：yxd |
| 最后编审: | 2020-11-09：yxd |
| 阅读次数: | 54 |