图 书 馆
基于生理学的PK-sim5模型：介绍和演示PK-Sim 5 for Physiology Based PK modelling: Introduction and Demonstration |
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| 课程网址: | http://videolectures.net/mdo2014_kanacher_pk_modelling/ |
| 主讲教师: | Tobias Kanacher |
| 开课单位: | 拜耳技术服务有限公司 |
| 开课时间: | 2014-07-21 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Physiology-based pharmacokinetic models (PBPK) describe adsorption, distribution, metabolisation and excretion of drugs in the human body based on a large amount of prior physiological knowledge. Specific physiological information quantifying for example blood flow rates or relative tissue-specific gene-expression is explicitly provided in the structure of PBPK models. Most other parameters can be calculated from the physicochemical properties of the compound which is under investigation such as the lipophilicity and the molecular weight. PBPK models can in particular be used to mechanistically investigate the different processes underlying drug pharmacokinetics. Using the software PK-Sim, we here provide an introduction to PBPK modelling which allows the user to independently implement a first model model. |
| 关 键 词: | 生理学; 药物; 药代动力学模型 |
| 课程来源: | 视频讲座网 |
| 数据采集: | 2020-11-11：yxd |
| 最后编审: | 2020-11-11：yxd |
| 阅读次数: | 1697 |