0


自己动手做生物学

Do-It-Yourself Biology
课程网址: http://videolectures.net/mitworld_kuldell_shetty_diyb/  
主讲教师: Natalie Kuldell; Reshma Shetty
开课单位: 麻省理工学院
开课时间: 2011-10-10
课程语种: 英语
中文简介:
受生物工程巨大潜力的启发,普通人正在寻找他们内心的弗兰肯斯坦——医生,而不是怪物。两位熟悉培养皿和烧杯的演讲者与麻省理工学院博物馆的观众讨论了自己动手生物学的可能性和缺陷。 Natalie Kuldell在展示1980年Omni杂志的广告时,回顾了过去几十年计算机工程的巨大变化——从20磅的PC到笔记本电脑和手提电脑。相比之下,她感叹道,今天的基因工程在很大程度上仍然类似于1980年的前身——将DNA片段插入大肠杆菌等生物体。她认为计算机工程之所以能取得这样的飞跃,是因为它的技术对业余爱好者来说非常普遍,而业余爱好者帮助推动了许多进步。一个新生的自助(DIY)社区认为,生物技术的发展速度没有现在这么快,也不会,直到更多的人能够接触到生物的基本组成部分。 合成生物学的目标是使新的生物形式更容易设计。库尔德尔抱怨说:“我的大部分时间都花在做我需要做的实验上。但在生物学中,构建生物组成部分和简化过程是很困难的,因为生物系统是复杂的、不可预测的。在厨房里使用“特百惠、温度计和基因工程”的业余爱好者能在家里“发现”一些非凡的生物技术吗?” Reshma Shetty认为,工程生物不仅可以感知环境中的有毒金属或确定海水是否受到污染。她可以“想象一个DIY生物工程师……做一些更梦幻、更有抱负的事…。你自己种房子怎么样?谢蒂描述了一个家庭实验,可以让细菌闻起来像香蕉。谢蒂说,这只是一个小小的壮举,但要想取得重大成就,对科学做出真正的贡献,DIY生物学家需要生物工程友好型生物,这种生物可以作为常见的模型,安全、易于生长“并且使用起来很有趣”。候选生物包括苔藓,一种叫做不动杆菌的易于生长的细菌,以及嗜盐的盐生细菌。通过给人们正确的工具,“他们可以创造一些有趣的和有创造性的东西,别人可以欣赏。”
课程简介: Inspired by the vast potential of bioengineering, ordinary people are seeking their inner Frankenstein -- doctor, not monster. Two speakers who know their way around Petri dish and beaker discuss the possibilities and pitfalls of do-it-yourself biology with an MIT Museum crowd. Showing ads from a 1980 Omni magazine, Natalie Kuldell reflects on the vast changes in computer engineering in the past few decades – from 20-lb PCs to laptops and handhelds. In contrast, she laments, genetic engineering today still resembles in large part its 1980 antecedents -- inserting bits of DNA into organisms like E. coli. She avers that computer engineering made such leaps because its technology was widely available to amateurs, who helped drive many advances. Biotech hasn’t moved as fast, and won’t, believes a nascent do-it-yourself (DIY) community, until basic components of biology become accessible to a larger population. Synthetic biology aims to make new biological forms easier to engineer. Kuldell complains that “much of my time is spent doing things to do the experiments I need to do. It would be terrific not to have to build things in advance.” But building biological components and streamlining processes is difficult in biology, because biosystems are complex, and unpredictable. Can amateurs working with “Tupperware, thermometers and genetic engineering in the kitchen” discover “something remarkable doing their biology at home?” Reshma Shetty thinks engineered organisms can do more than sense toxic metals in the environment or determine whether seawater is contaminated. She can “imagine a DIY bioengineer…doing something more fantastical, ambitious…. What about growing your own house?” Shetty describes a home experiment that can make bacteria smell like bananas. This is a small feat, but to achieve something significant, a real contribution to science, Shetty says DIY biologists need bio-engineered friendly organisms that will serve as common models, safe, easy to grow “and fun to use.” Candidates include moss, an easy to grow bacterium called Acinetobacter, and the salt-loving Halobacterium. By giving people the right tools, “they can build something fun and creative others can appreciate.”
关 键 词: 生物技术; 生物工程; 生物学
课程来源: 视频讲座网
数据采集: 2020-11-22:yxd
最后编审: 2021-09-15:zyk
阅读次数: 84