图 书 馆
分支形态发生中的自组织原理Self-organizing principles in branching morphogenesis |
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| 课程网址: | http://videolectures.net/kolokviji_hannezo_branching_morphogenesi... |
| 主讲教师: | Edouard Hannezo |
| 开课单位: | 奥地利科学技术学院 |
| 开课时间: | 2018-05-23 |
| 课程语种: | 英语 |
| 中文简介: |  分支器官的形态发生仍然是一个有待研究的课题。尽管对基本的信号通路了解很多，但仍不清楚如何编码分支器官的宏观特征，包括其大小，网络拓扑和空间模式。在这里，我们表明，在小鼠的乳腺，肾脏和人前列腺中，这些特征可以在分支和消除随机行走的单一统一框架内进行定量解释。基于大规模器官重建的定量分析和增殖动力学测量结果，我们提出形态发生来自等电位尖端的增殖活动，这些尖端随机分支并随机探索其环境，但在空间上进行中性竞争，在邻近导管附近时变得增殖失活。这些结果表明，复杂的分支上皮结构是一个自组织的过程，依赖于非常简单但通用的规则，而没有依赖于严格的确定性的基因编程事件序列。 |
| 课程简介: | The morphogenesis of branched organs remains a subject of abiding interest. Although much is known about the underlying signaling pathways, it remains unclear how macro-scopic features of branched organs, including their size, network topology, and spatial patterning, are encoded. Here, we show that, in mouse mammary gland, kidney, and hu-man prostate, these features can be explained quantitatively within a single unifying framework of branching and annihilating random walks. Based on quantitative analyses of large-scale organ reconstructions and proliferation kinetics measurements, we propose that morphogenesis follows from the proliferative activity of equipotent tips that stochas-tically branch and randomly explore their environment but compete neutrally for space, becoming proliferatively inactive when in proximity with neighboring ducts. These results show that complex branched epithelial structures develop as a self-organized process, reliant upon a strikingly simple but generic rule, without recourse to a rigid and determin-istic sequence of genetically programmed events. |
| 关 键 词: | 分支器官; 增殖动力学; 基因编程事件序列 |
| 课程来源: | 视频讲座网 |
| 数据采集: | 2020-11-22：cjy |
| 最后编审: | 2020-11-22：cjy |
| 阅读次数: | 57 |