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轻度认知功能障碍和帕金森病患者静息状态功能连接的研究

Resting state functional connectivity in patients with mild cognitive impairment and Parkinson’s disease
课程网址: http://videolectures.net/snc2015_slana_functional_connectivity/  
主讲教师: Anka Slana
开课单位: 卢布尔雅那大学
开课时间: 2015-09-07
课程语种: 英语
中文简介:
功能连通性是功能磁共振成像(fMRI)数据分析的一种相对新颖的技术,它通过分析大脑活动随时间变化的自发波动的相关性来识别大脑区域之间的连通性。研究表明,形成功能网络的大脑区域在静息状态下呈现出连贯的大胆波动,这种功能结构在各种脑疾病中受到干扰。本研究的目的是探讨轻度认知障碍患者与帕金森氏症伴或不伴PD相关轻度认知障碍患者脑连接的可能差异,这些差异可作为疾病早期诊断的生物标志物。72名参与者——21名健康人,22名轻度认知障碍患者,14名帕金森病患者,15名帕金森病相关轻度认知障碍患者接受静息状态功能磁共振成像。关于网络连通性和整体大脑整合的群体差异的调查结果将被报告和讨论。
课程简介: Functional connectivity is a relatively novel technique of fMRI data analysis, which focuses on identifying connectivity between brain regions by analysing correlations of spontaneous fluctuations of brain activity across time. It was shown that brain regions that form functional networks show coherent BOLD fluctuations under resting conditions, and that this functional architecture is disturbed in various brain disorders. The aim of this study was to explore possible differences in brain connectivity in patients with mild cognitive impairment and Parkinson’s disease with and without PD related mild cognitive impairment, which could serve as diagnosis biomarkers in early stages of the disease. 72 participants—21 healthy individuals, 22 participants with mild cognitive impairment, 14 participants with Parkinson’s disease, 15 participants with Parkinson’s disease related mild cognitive impairment—underwent resting-state functional magnetic resonance imaging. Results of investigation of group differences in network connectivity and global brain integration will be reported and discussed.
关 键 词: 大脑活动; 帕金森氏; 脑部疾病
课程来源: 视频讲座网
数据采集: 2020-12-21:yxd
最后编审: 2020-12-21:yxd
阅读次数: 51