图 书 馆
组织蛋白酶在肿瘤诊治中的作用轨迹The track of cathepsins in diagnosis and therapy of cancer |
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| 课程网址: | http://videolectures.net/NIBsimpozij2017_kos_therapy_cancer/ |
| 主讲教师: | Janko Kos |
| 开课单位: | 卢布尔雅那大学 |
| 开课时间: | 2017-12-09 |
| 课程语种: | 英语 |
| 中文简介: |  几十年前，溶酶体半胱氨酸肽酶（组织蛋白酶）被认为是恶性过程的促进剂。我们与 Tamara Lah 合作，广泛评估了它们在不同类型癌症的发展和进展中的作用。通过开发特定试剂和诊断分析，我们评估了它们在预测诊断、预后和治疗反应方面的价值，为癌症患者的个性化治疗铺平了道路。我们的研究后来通过开发新的半胱氨酸组织蛋白酶抑制剂和特定靶向有害肽酶的递送系统，扩展到抗癌治疗的新模式。最近，半胱氨酸组织蛋白酶被认为是抗肿瘤免疫反应的重要参与者。它们可以被肿瘤细胞探索，以防止它们被免疫细胞识别或削弱免疫细胞的细胞毒性，从而杀死肿瘤细胞。讲座将介绍我们合作工作的主要成就，并为进一步活动提出建议。 |
| 课程简介: | Decades ago lysosomal cysteine peptidases – the cathepsins, have been suggested as promotors of malignant processes. In collaboration with Tamara Lah we extensively evaluated their role in development and progression of different types of cancer. By developing specific reagents and diagnostic assays we assessed their values to predict diagnosis, prognosis and response to therapy, paving the way towards personalized treatment of cancer patients. Our research was later extended on new modes of anti-cancer therapy by developing new inhibitors of cysteine cathepsins and delivery systems for specific targeting of harmful peptidases. More recently, cysteine cathepsins have been recognized as important players of anti-tumor immune response. They can be explored by tumor cells to prevent their recognition by immune cells or to impair immune cell cytotoxicity and consequently tumor cell killing. The lecture will present key achievements of our collaborative work and suggest directions for further activities. |
| 关 键 词: | 组织蛋白酶; 预测诊断; 抗癌治疗 |
| 课程来源: | 视频讲座网 |
| 数据采集: | 2021-07-01：liyy |
| 最后编审: | 2021-07-01：liyy |
| 阅读次数: | 48 |