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NLP与植物膜结合的结构研究Structural insights into NLP binding to plant membranes |
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| 课程网址: | http://videolectures.net/forum40_lenarcic_structural_insights_nlp... |
| 主讲教师: | Tea Lenarčič |
| 开课单位: | 斯洛文尼亚国家化学研究所 |
| 开课时间: | 2018-11-27 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Necrosis and ethylene-inducing peptide 1 (Nep1)-like proteins (NLPs) are secreted by several phytopathogenic micro-organisms. They trigger leaf necrosis and immunity-associated responses in various dicotyledonous plants. We identified glycosylinositol phosphorylceramides (GIPC), a major class of plant sphingolipids, as target molecules for NLP binding to plasma membranes. X-ray crystallography revealed that NLP forms complexes with terminal hexose moieties. NLP binding to GIPC head groups induces several conformational changes within the toxin that precedes membrane attachment and host cell lysis. This study unveils early steps of NLP cytolysin action and explains why dicot plants are NLP toxin-sensitive whereas monocot plants are not. |
| 关 键 词: | 植物病原微生物; NLP溶细胞素作用; 植物鞘脂 |
| 课程来源: | 视频讲座网 |
| 数据采集: | 2021-11-05：zkj |
| 最后编审: | 2021-11-05：zkj |
| 阅读次数: | 56 |