图 书 馆
蛋白质产生率的mRNA序列决定因素mRNA sequence determinants of protein production rate |
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| 课程网址: | http://videolectures.net/biophysics2018_nossan_production_rate/ |
| 主讲教师: | Juraj Szavits Nossan |
| 开课单位: | 爱丁堡大学 |
| 开课时间: | 2018-07-09 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Protein synthesis is of paramount importance to every living cell. The major challenge in molecular biology is to understand how information that is encoded in an mRNA transcript affects the rate of mRNA translation and therefore the overall protein production (1). Computational models of mRNA translation that aim to address this challenge have a long history dating as back to 1960s (2,3). So far these models had very limited power in predicting determinants of translation efficiency, owning to the fact that ribosome dynamics operates out of equilibrium and is therefore beyond the realm of equilibrium statistical physics. I present here a novel mathematical method for solving a standard biophysical model of translation. The solution shows an excellent agreement when compared to numerical genome-wide simulations of S. cerevisiae transcript sequences and predicts that the first 10 codons, together with the value of the initiation rate, are the main determinants of protein production rate. I also discuss potential experiments for testing these predictions. |
| 关 键 词: | 蛋白质合成; 分子生物学; 蛋白质产生速率 |
| 课程来源: | 视频讲座网 |
| 数据采集: | 2021-11-12：zkj |
| 最后编审: | 2021-11-12：zkj |
| 阅读次数: | 45 |