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考虑醛糖还原酶特性的基于配体的药物设计Ligand-based drug design considering specific features of aldose reductase |
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| 课程网址: | http://videolectures.net/biophysics2018_majekova_aldose_reductase... |
| 主讲教师: | Magdalena Majekova |
| 开课单位: | 苏黎世大学 |
| 开课时间: | 2018-07-09 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Aldose reductase is as a rate-limiting enzyme in the polyol pathway, one of the main mechanisms of glucose toxicity. Inhibitors of aldose reductase showed to be helpful in prevention of diabetic complications and other disorders connected related to a glucose toxicity. Aldose reductase (EC: 1.1.1.21), the three-dimensional structure of AR has been explored in many research works, belongs to the aldo-keto reductase superfamily. Aldose reductase catalyzes many substrates, as lipid aldehydes, methyl glyoxal, aliphatic and aromatic aldehydes, daunorubicin, doxorubicin, etc. With the exception of PGH2 transformation to PGD2, which proceeds in the absence of cofactors NADPH or NADP + , all other known catalytic processes of AR are NADPH-dependent. We present a survey of ligand-based drug design, which resulted in identification of efficient inhibitors (1), with highlighting the specific features of aldose reductase. |
| 关 键 词: | 醛糖还原酶; 催化; 基于配体 |
| 课程来源: | 视频讲座网 |
| 数据采集: | 2021-11-13：zkj |
| 最后编审: | 2021-11-13：zkj |
| 阅读次数: | 50 |