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睡眠振荡改变作为帕金森病胆碱酯酶病的早期生物标志物Altered sleep oscillations as early biomarkers of Parkinson’s disease cholinopathy |
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| 课程网址: | http://videolectures.net/biophysics2018_saponjic_parkinson_diseas... |
| 主讲教师: | Jasna Saponjic |
| 开课单位: | 贝尔格莱德大学 |
| 开课时间: | 2018-07-09 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Rhythmic oscillations in the electroencephalographic (EEG) local field potentials underlie the basis of behavioral states and neurological diseases through coherent binding of the cooperating neuronal ensembles. Biophysical methodological approaches enabled us to evidence an augmented cortical activation during non-rapid-eye-movement (NREM) and rapid-eye- movement (REM) sleep, expressed as a long-lasting augmentation of EEG beta vs. delta amplitude attenuation during NREM, with no change of sleep architecture during Parkinson’s disease ( PD) cholinopathy in rat. Moreover, two REM states emerged in the motor cortex (“theta coherent REM” and “sigma coherent REM”), with distinct cortical drives, expressed as the impaired theta and sigma oscillations propagation . T he hallmarks of earlier aging onset during PD cholinopathy is the REM sleep “enriched“ with sigma activity in the motor cortex alongside the broadly augmented propagation of EEG oscillations to the dorsal nuchal muscles. This unique REM sleep was underlined by the altered sleep spindles pattern and dynamic, reflecting the reorganization at thalamocortical level. Furthermore, there was a sustainable increase of EEG delta vs. beta amplitude decrease in the hippocampus during NREM sleep alongside the altered high voltage sleep spindle (HVS) dynamic during REM sleep, followed by hypokinesia. In order how they occurred, the h ippocampal NREM sleep disorder, altered HVS dynamics during REM sleep in the hippocampus and motor cortex, and delayed „hypokinesia” may serve as biomarkers of PD onset and progression. Understanding the role of brain oscillations as possible biomarkers of brain function is still a challenge, and despite extensive research, their role is still not well established. |
| 关 键 词: | 帕金森; 胆碱酯酶病; 脑震荡 |
| 课程来源: | 视频讲座网 |
| 数据采集: | 2021-11-13：zkj |
| 最后编审: | 2021-11-13：zkj |
| 阅读次数: | 60 |