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第7讲-亲核取代工具-立体化学、速率定律、底物、亲核试剂、离开基团Lecture 7 - Nucleophilic Substitution Tools - Stereochemistry, Rate Law, Substrate, Nucleophile, Leaving Group |
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| 课程网址: | http://videolectures.net/yalespan125bs2011_mcbride_lec07/ |
| 主讲教师: | J. Michael McBride |
| 开课单位: | 耶鲁大学 |
| 开课时间: | 2014-08-19 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | SN2 substitution provides an example of establishing the mechanism of a chemical reaction by disproving all the alternatives. Five general pathways are envisioned (two-step involving either pentavalent or trivalent carbon intermediates, and one-step). They can be discriminated by applying a variety of experimental tools including stereochemistry (Walden inversion), rate law (second order and pseudo first order), and the variation of rate constant with changes in the substrate (steric hindrance and ring strain), and with changes in nucleophile or leaving group. Classic experiments by Kenyon and Phillips and by Bartlett and Knox established the nature of Walden inversion. |
| 关 键 词: | 立体化学; 速率定律; 亲核基团 |
| 课程来源: | 视频讲座网 |
| 数据采集: | 2021-11-13：zkj |
| 最后编审: | 2021-11-13：zkj |
| 阅读次数: | 41 |