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第6讲-勃朗斯特酸度和亲核取代的普遍性Lecture 6 - Brønsted Acidity and the Generality of Nucleophilic Substitution |
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| 课程网址: | http://videolectures.net/yalespan125bs2011_mcbride_lec06/ |
| 主讲教师: | J. Michael McBride |
| 开课单位: | 耶鲁大学 |
| 开课时间: | 2014-08-19 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | The coincidentally substantial extent of ionic dissociation of water provides an example of Brønsted acidity, or nucleophilic substitution at hydrogen. Relative pKa values are insensitive enough to solvent that they provide insight on the role of energy-match, overlap, and resonance in ionic dissociation. The titration of alanine in water illustrates the experimental determination of pKa values and the phenomenon of buffering. The limited pKa scale in water can be extended dramatically by titration in other solvents, providing one of the best ways to measure many "effects" in organic chemistry. A wide range of important organic reactions discovered in the 19th century and many biochemical reactions can be understood under the rubric of nucleophilic substitution. |
| 关 键 词: | 水离子离解; 亲核取代; 有机反应 |
| 课程来源: | 视频讲座网 |
| 数据采集: | 2021-11-17：zkj |
| 最后编审: | 2021-11-17：zkj |
| 阅读次数: | 57 |