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第27讲-三苯基甲基和羰基化学导论Lecture 27 - Triphenylmethyl and an Introduction to Carbonyl Chemistry |
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| 课程网址: | http://videolectures.net/yalespan125bs2011_mcbride_lec27/ |
| 主讲教师: | J. Michael McBride |
| 开课单位: | 耶鲁大学 |
| 开课时间: | 2014-08-19 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Painstaking studies of his "hexaphenylethane" and its reactivity convinced Gomberg that he had prepared the first trivalent carbon compound, triphenylmethyl radical, the discovery of which marked the emergence of fundamental organic chemistry in America. Isotopic labeling could decide whether protonated cyclopropane plays a role in Friedel-Crafts alkylation. C-13 NMR spectra of aldehydes and ketones show how characteristic chemical shifts are established empirically. The carbonyl group is thermodynamically stable but kinetically reactive. Its acid- and base-catalyzed reactions often involve loss of α-proton to form an enol or enolate intermediate. Carboxylic acids display four fundamentally different reaction patterns. Acid-catalyzed hydrolysis of acetals illustrates a multistep reaction mechanism involving the carbonyl group. |
| 关 键 词: | 三苯基甲基自由基; 羰基; 多步骤反应机理 |
| 课程来源: | 视频讲座网 |
| 数据采集: | 2021-11-18：zkj |
| 最后编审: | 2021-11-18：zkj |
| 阅读次数: | 52 |