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第36讲-α-反应性和缩合反应Lecture 36 - α-Reactivity and Condensation Reactions |
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| 课程网址: | http://videolectures.net/yalespan125bs2011_mcbride_lec36/ |
| 主讲教师: | J. Michael McBride |
| 开课单位: | 耶鲁大学 |
| 开课时间: | 2014-08-19 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | As in many synthetic procedures, an important challenge in ketone alkylation is choosing reagents and conditions that allow control of isomerism and of single vs. multiple substitution. β-Dicarbonyl compounds allow convenient alkylation and preparation of ketones and carboxylic acids. The aldol condensation, in which an α-position adds to a carbonyl group to generate a β-hydroxy- or an α,β-unsaturated carbonyl compound, can be driven to completion by removal of water. The Robinson annulation reaction is an important example of conjugate addition to α,β-unsaturated carbonyl compounds. α-Acylation of esters as in the Claisen condensation is a key step in the biosynthesis of fatty acids. Determining the constitutional structure of sugars posed a daunting challenge to early carbohydrate chemists. |
| 关 键 词: | 酮烷基化; 共轭加成反应; 缩合反应 |
| 课程来源: | 视频讲座网 |
| 数据采集: | 2021-11-18：zkj |
| 最后编审: | 2021-11-18：zkj |
| 阅读次数: | 46 |