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IDH1和IDH2突变是人类癌症中的朋友和敌人IDH1 and IDH2 mutations as friends and foes in human cancer |
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| 课程网址: | http://videolectures.net/nib_molenaar_human_cancer/ |
| 主讲教师: | Remco J. Molenaar |
| 开课单位: | 阿姆斯特丹大学 |
| 开课时间: | 2018-05-07 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | The enzyme isocytrate dehydrogenase IDH is very important in carbohydrate metabolism, and when mutated in cancer cells, the metabolic pathway is drastically altered. Somatic mutations in IDH1/2 occur in 20% of patients with myeloid neoplasms, including glioma, melanoma, prostate cancer and acute myeloid leukemia. Cancer patients with IDH1/2 mutations have a relatively prolonged survival compared with IDH1/2 wild-type counterparts. The underlying molecular mechanism in various subtypes of cancer have been demonstrated to also involve altered redox homeostasis and reduced DNA damage repair. Furthermore, the ongoing clinical trials in which we repurpose already-approved and off-patent drugs for the treatment of IDH1/2-mutated cancers will be discussed. |
| 关 键 词: | 异钇酸脱氢酶IDH; 癌细胞; 癌细胞 |
| 课程来源: | 视频讲座网 |
| 数据采集: | 2021-12-10：zkj |
| 最后编审: | 2021-12-20：liyy |
| 阅读次数: | 68 |