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轻度认知障碍的神经心理学标志物

Neuropsychological markers of mild cognitive impairment
课程网址: http://videolectures.net/snc2015_brezovar_cognitive_impairment/  
主讲教师: Simon Brezovar
开课单位: 卢布尔雅那大学
开课时间: 2015-09-07
课程语种: 英语
中文简介:
轻度认知障碍(MCI)表现为临床上显著的认知能力下降,日常功能保持不变。大量研究表明,MCI患者出现痴呆症状的风险增加。减缓痴呆症症状的可能性与早期诊断和干预密切相关。因此,正确、可靠的MCI诊断对于临床医生、患者及其护理人员在后续治疗中做出重要决策起着非常重要的作用。神经心理学评估旨在解决有关认知衰退水平和类型的问题。在MCI文献中,我们可以找到大量的研究,其中神经心理学数据与其他检查(如脑脊液、MRI、EEG)相结合。这些研究通常解决了以下问题:哪种生物标志物组合是预测个体痴呆进展的最佳组合。我们研究的神经心理学部分的目的是(i)找到预测MCI向痴呆转化的最佳神经心理学测量方法,(ii)通过计算稳健记忆和非记忆成分来分离不同的MCI亚组,(iii)将最具预测性的神经心理学变量与其他检查相结合,(iv)解决MCI患者的神经心理学分数与不同认知控制模式之间的关系。我们招募了80名参与者(20名对照组、20名MCI、20名帕金森病(PB)和20名患有MCI的PB),以获取有关其认知功能的信息。
课程简介: Mild cognitive impairment (MCI) represents clinically significant cognitive decline with preserved everyday functioning. Vast amount of studies have shown that patients with MCI have increased risk for development symptoms of dementia. The probability of slowing down symptoms of dementia is closely related with an early diagnosis and intervention. Therefore, correct and reliable diagnosis of MCI plays very important role for clinicians, patients and their care-givers in making important decisions in subsequent treatment. Neuropsychological assessment aims to address question regarding level and type of cognitive decline. In the MCI literature we can find large amount of studies where neuropsychological data have been combined with other examinations (e.g. CSF, MRI, EEG). These studies have usually addressed question which combination of biomarkers are optimal in predicting individual progress to dementia. The aim of neuropsychological part of our study was (i) to find the neuropsychological measurements which are the best in predicting conversion from MCI to dementia, (ii) to separate different MCI subgroups by means of calculating robust memory and non-memory components, (iii) to combine the most predictive neuropsychological variables with other examinations and (iv) to address the question how are neuropsychological scores in MCI patients related to different modes of cognitive control. We recruited 80 participants (20 controls, 20 MCI, 20 Parkinson’s disease (PB), and 20 PB with MCI) to obtain the information about their cognitive functions.
关 键 词: 轻度认知障碍; 个体痴呆; 生物标志物
课程来源: 视频讲座网
数据采集: 2021-12-11:nkq
最后编审: 2021-12-11:nkq
阅读次数: 47