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颞叶癫痫语言网络的图论分析
Graph-theoretical analysis of language networks in temporal lobe epilepsy |
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| 课程网址: |
http://videolectures.net/snc2015_gosar_lobe_epilepsy/
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| 主讲教师: |
David Gosar
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| 开课单位: |
卢布尔雅那大学
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| 开课时间: |
2015-09-07
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| 课程语种: |
英语
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| 中文简介: |
对人脑功能连通性的研究为癫痫患者的认知功能障碍和代偿带来了重要的启示。图论在这些分析中的应用为理解癫痫对认知的影响提供了一种新颖而有力的方法。在正常人群和50%以上的耐药颞叶（TLE）患者中，左半球在语言方面占主导地位。然而，在癫痫手术评估期间，发现大约20-40%的TLE患者在左半球处于临时麻醉状态时能够说话。我们选择使用两种功能磁共振语言任务（语言流畅性、动词生成）对6名此类患者进行癫痫相关语言功能障碍的研究。通过将他们的功能磁共振激活和连通性与6名具有典型语言表征的TLE患者和9名对照参与者进行比较，我们发现非典型语言表征与双侧大脑激活以及右侧颞上回和右侧岛叶的更高连通性相关。网络分析还表明，TLE患者的语言网络效率低于对照组。较低的神经心理学分数（波士顿命名测验和言语智商）与这种更高的网络效率低下和无法抑制与任务无关的大脑区域有关。癫痫发作的早期年龄与非典型的语言激活和连通性有关。我们的结果表明，基于图论的分析有助于更好地理解癫痫是如何影响认知的。在TLE患者中，他们指出，无法脱离与任务无关的大脑区域可能是认知功能障碍的一个重要因素。
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| 课程简介: |
Studying functional connectivity in the human brain has brought about significant insight into cognitive dysfunction and compensation in individuals with epilepsy. The utilization of graph-theory in these analyses offers a novel and powerful method to understand the impact of epilepsy on cognition. Among the normal population and over 50% of patients with drug drug-resistant temporal lobe (TLE) the left hemisphere is dominant for language. However, during evaluation for epilepsy surgery about 20-40% of TLE patients are found who are able to speak while their left hemisphere is under temporary anesthesia. We chose to study epilepsy-related language dysfunction by using two fMRI language tasks (verbal fluency, verb generation) in six such patients. By comparing their fMRI activation and connectivity to that of six TLE patients with typical language representation and nine control participants we found that atypical language representation is associated with bilateral brain activation and higher connectivity in the right superior temporal gyrus and right insula. Network analysis also indicated that TLE patients had less efficient language networks than control participants. Poorer neuropsychological scores (Boston Naming Test and verbal IQ) were associated with this gre ater network inefficiency and inability to inhibit task-irrelevant brain regions. Earlier age of seizure onset was found to be associated with atypical language activation and connectivity. Our results show that graph-theory-based analyses can help better understand how epilepsy impacts cognition. In TLE patients, they indicate that an inability to disengage task non-relevant brain regions may be a vital factor in cognitive dysfunction.
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| 关 键 词: |
癫痫患者; 图论; 认知功能障碍
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| 课程来源: |
视频讲座网
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| 数据采集: |
2021-12-11：nkq
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| 最后编审: |
2021-12-11：nkq
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| 阅读次数: |
67
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