内侧前额叶皮质在大鼠不确定性决策中的作用The role of medial prefrontal cortex in uncertainty-based decision making in rats |
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课程网址: | http://videolectures.net/snc2015_mikus_prefrontal_cortex/ |
主讲教师: | Nace Mikuš |
开课单位: | 维也纳医科大学 |
开课时间: | 2015-10-01 |
课程语种: | 英语 |
中文简介: | 前额叶皮层在人类的决策中起着至关重要的作用,前额叶亚区具有一定程度的功能特化。目前的技术水平意味着前额叶皮质的外侧、腹侧和内侧区域可能编码决策过程的不同方面,即:分别代表不同的环境状态、预测替代选择的不同结果和更新替代行动的可取性。此外,背外侧皮质被认为参与基于风险的决策。大鼠的内侧前额叶皮质和人类的前扣带回皮质和背外侧前额叶皮质似乎有一些共同的功能和解剖学特征。为了进一步阐明前额叶皮质的特定部分如何参与基于奖励的决策和风险处理,我们记录了大鼠在执行基于风险的决策任务时内侧前额叶皮质细胞的活动。为此,老鼠在有固定奖励的安全手臂和有风险的手臂之间进行选择,在这两种手臂上,老鼠在不同的区块中以不同的概率获得更大的奖励。使用强化学习模型对大鼠的行为进行建模,我们观察到与选择和结果值相关的细胞,以及可能参与动物对奖励的内部表征或与每个选择相关的积极结果概率的其他细胞。此外,我们还研究了奖励的不确定性如何反映在细胞的活动中。总的来说,我们的数据表明,行为任务的不同方面受到前额叶神经元不同活动模式的支持。 |
课程简介: | The prefrontal cortex plays a crucial role in decision making in humans with a certain degree of functional specialisation of the prefrontal subregions. The current state of the art implies that the lateral, ventral and medial areas of the prefrontal cortex might encode different aspects of the decision process, namely: representing various states of the environment, predicting the different outcomes of alternative choices and updating the desirability of alternative actions, respectively. Additionally, the dorsolateral cortex is believed to be involved in risk-based decision making. The medial prefrontal cortex in rats and the anterior cingulate cortex and dorsolateral prefrontal cortex in humans seem to share some functional and anatomical features. To shed further light on how specific parts of the prefrontal cortex contribute to reward-based decision making and processing of risk we have recorded the activity of cells in the medial prefrontal cortex in rats while performing a risk-based decision task. For this the rat chooses between a safe arm with a fixed reward and a risky arm where it gets a bigger reward with different probabilities across different blocks. Using a reinforcement learning model to model the behaviour of the rat, we observed cells that are linked to choice and outcome value, othercells that might be involved in the animals’ internal representation of the reward or the probability of positive outcome related to each choice. Furthermore we investigated how the uncertainty of the rewards reflects in the activity of cells. Overall, our data indicate that different aspects of the behavioural task are supported by divers activity patterns of prefrontal neurons. |
关 键 词: | 前额叶皮层; 风险; 细胞 |
课程来源: | 视频讲座网 |
数据采集: | 2021-12-11:nkq |
最后编审: | 2021-12-11:nkq |
阅读次数: | 52 |