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大鼠（外侧）眶额皮质升档、降档和阻滞结果的神经编码
Neural coding of upshifted, downshifted, and blocked outcomes in the rat (lateral) orbitofrontal cortex |
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| 课程网址: |
http://videolectures.net/rldm2015_schoenbaum_neural_coding/
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| 主讲教师: |
Geoff Schoenbaum
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| 开课单位: |
美国卫生与公共服务部
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| 开课时间: |
2015-07-28
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| 课程语种: |
英语
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| 中文简介: |
关于眼眶额叶皮质编码什么样的结果信息以支持结果引导行为，存在很多争论。一个模型是，神经元的主要工作是将信息提取到单一的通用价值货币。根据另一个模型，眶额神经元发出关于结果的更具体信息。这些信息将与确定价值相关，特别是相对于其他类似和不同的结果，但它从根本上不是一个价值信号。与后者一致的是，我们在大鼠中报告，眶额皮质1）对许多本身不需要价值的行为至关重要，2）在需要价值时并不重要。在这里，我们使用一种这样的操作——阻断和解除阻断——来直接询问这种参与是如何反映在神经活动中的。我们使用阻断作为一种控制操作，以隔离关于结果的哪些关联信息可用于进入与条件刺激的关联，然后通过操纵结果的值或其他特征来解除对学习的阻断。我们报告说，眶额神经元对预测结果变化的线索进行激发，而不考虑这些变化是改变价值还是毫无价值。这些结果表明，大鼠（外侧）眶额皮质的神经元对信号传递结果特征的兴趣至少与对信号传递值的兴趣一样简单，并且进一步表明，值本身可能是这些特征中最好的一个。
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| 课程简介: |
There is much debate over what information about outcomes the orbitofrontal cortex encodes in order to support outcome-guided behavior. One model is that the primary job of neurons there is to distill information down to a single common value currency. By another model, orbitofrontal neurons signal more specific information about outcomes. Such information would be relevant to determining value, particularly relative to other similar and dissimilar outcomes, but it is not fundamentally a value signal. Consistent with the latter, we have reported in rats that the orbitofrontal cortex 1) is critical to a number of behaviors that do not require value per se and 2) not critical when value is required. Here we use one such manipulation - blocking and unblocking - to ask directly how this involvement is reflected in neural activity. We use blocking as a control manipulation to isolate what associative information about the outcome is available to enter into an association with a conditioned stimulus, then we unblock learning by manipulating the value or other features of the outcome. We report that orbitofrontal neurons fire to cues that predict changes in outcomes largely without regard to whether those changes alter value or are largely valueless. These results suggest that neurons in rat (lateral) orbitofrontal cortex are at least as interested in signaling outcome features as the are in signaling value in any sort of simple way, and further suggest that value itself may be best conceived as just one of these features.
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| 关 键 词: |
眼眶额叶皮质编码; 神经元; 信号传递值
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| 课程来源: |
视频讲座网
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| 数据采集: |
2021-12-25：zkj
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| 最后编审: |
2021-12-25：zkj
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| 阅读次数: |
72
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