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DNA的魔力生命的分子及其结构

The magic of DNA, the molecule of life and its structures
课程网址: http://videolectures.net/zv_plavec_magic_of_dna/  
主讲教师: Janez Plavec
开课单位: 卢布尔雅那化学研究所
开课时间: 2018-04-13
课程语种: 英语
中文简介:
脱氧核糖核酸(脱氧核糖核酸,DNA)由一系列携带基因指令的核苷酸所知,这些基因指令用于所有已知生物体和许多病毒的生长、发育、功能和繁殖。DNA分子最广为人知的结构由两条相互作用形成双螺旋的链组成。端粒序列和促进区显示出富含鸟嘌呤的区域,这些区域在衰老和基因表达调控过程中非常重要。这些序列特性及其功能与由称为G-四链体的四条链组成的结构有关。核磁共振(NMR)可以研究DNA分子结构与其生物活性或作用方式之间的相关性。NIC的NMR中心已确定并在国际期刊上发表了DNA片段中鸟嘌呤丰富区域采用的新的四重结构,从而有助于理解它们在神经发育和神经疾病、骨和软骨发育异常、癌症以及基本细胞过程中的作用。
课程简介: Deoxyribonucleic acid, DNA, is known by a series of nucleotides that carry genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses. The most well-known structure of the DNA molecule consists of two strands that interact with one another forming a double helix. Telomeric sequences and promotion regions exhibit guanine-rich regions, which are important in the processes of aging and regulation of gene expression. These sequence properties and their functions are associated with structures consisting of four strands known as G-quadruplex. Nuclear magnetic resonance, NMR, enables studies of correlations between molecular structure of DNA and its biological activities or mode of action. NMR center at NIC has determined and published in international journals new quadruplex structures adopted by guanine-rich regions of DNA fragments thus contributing to understanding of their roles in neurodevelopment and neurological disorders, abnormalities in bone and cartilage development, cancer as well as basic cellular processes.
关 键 词: 脱氧核糖核酸; 携带基因指令; 核磁共振
课程来源: 视频讲座网
数据采集: 2022-03-26:zkj
最后编审: 2022-03-26:zkj
阅读次数: 37