图 书 馆
在额叶皮层工作记忆的神经机制Neural mechanisms of working memory in the prefrontal cortex |
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| 课程网址: | http://videolectures.net/eccs08_funahashi_nmowmitpc/ |
| 主讲教师: | Shintaro Funahashi |
| 开课单位: | 京都大学 |
| 开课时间: | 2008-10-17 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Working memory is a mechanism for short-term active maintenance of information as well as for processing maintained information. The dorsolateral prefrontal cortex (DLPFC) has been known to participate in working memory. The analysis of task-related DLPFC activity while monkeys performed a variety of working memory tasks revealed that delay-period activity is a neural correlate of a mechanism for temporary active maintenance of information, because this activity persisted throughout the delay period, showed selectivity to a particular visual feature, and was related to correct behavioral performances. On the other hand, information processing can be considered as a change of the information represented by a population of neurons during the progress of the trial. Using population vectors calculated by a population of task-related DLPFC activities, we demonstrated the temporal change of information represented by a population of DLPFC neurons during performances of spatial working memory tasks. Cross-correlation analysis using spike firings of simultaneously isolated pairs of neurons reveals widespread functional interactions among neighboring neurons, especially neurons having delay-period activity, and their dynamic modulation depending on the context of the trial. Functional interactions among neurons and their dynamic modulation could be a mechanism of information processing in the working memory processes. |
| 关 键 词: | 背外侧前额叶皮层; 信息处理; 工作记忆任务显示; 动态调制功能 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2020-10-14：yumf |
| 阅读次数: | 72 |