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均衡的空间工作记忆

Balanced spatial working memory
课程网址: http://videolectures.net/eccs08_hansel_bswm/  
主讲教师: David Hansel
开课单位: 勒内·笛卡尔大学
开课时间: 2008-10-17
课程语种: 英语
中文简介:
持续数秒的神经活动被认为是皮质中工作记忆的神经相关性。最近发现,在持续活动期间,穗列车高度不规则,甚至比自发活动更不规则。我们表明,如果人们认为神经元非线性与复发激发相结合,那么这种明显无害的特征就会引发一个根本性的困难。相反,我们认为所涉及的关键非线性是突触而非神经元。我们在网络模型的框架中评估该提议,该网络模型表示涉及空间工作记忆的前额叶皮层中的电路。这使我们认为最近在前额叶皮层锥体细胞突触中发现的短期可塑性在空间工作记忆中至关重要。
课程简介: Neural activity persisting for several seconds is thought to be the neural correlate of working memory in cortex. It was found recently that during persistent activity spike trains are highly irregular, even more irregular than in spontaneous activity. We show that this apparently innocuous feature raises a fundamental difficulty if one holds that neuronal nonlinearities combined with recurrent excitation underly activity persistence as usually assumed. Instead, we argue that the key nonlinearities involved are synaptic and not neuronal. We assess this proposal in the framework of a network model representing a circuit in prefrontal cortex involved in spatial working memory. This lead us to suggest that short term plasticity recently discovered in synapses made by pyramidal cells in prefrontal cortex is crucial in spatial working memory.
关 键 词: 神经活动; 不规则的自发活动; 非线性神经元; 空间工作记忆
课程来源: 视频讲座网
最后编审: 2020-10-14:yumf
阅读次数: 35