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电子健康记录时代的医学

Medicine in the Age of Electronic Health Records
课程网址: http://videolectures.net/kdd2014_shah_health_records/  
主讲教师: Nigam H. Shah
开课单位: 斯坦福大学
开课时间: 2014-10-07
课程语种: 英语
中文简介:
在EHR时代,有可能检查医生在临床实践中做出的决定的结果,以确定基于专家集体实践的护理模式产生证据。我们将讨论使用非结构化患者数据来监测不良药物事件、描述特定药物、识别标签外药物使用、发现“自然实验”以及为难以测试的临床假设生成基于实践的证据的方法。我们将描述如何在发出警报前几年检测药物之间的关联及其不良事件,以及如何计算药物相互作用的真实比率。我们将介绍使用患者特征矩阵以及关于药物、疾病和已知用法的先验知识来识别药物的新标签外用途的方法。我们将回顾一项自然实验,在该实验中,尽管有黑匣子警告,但仍有一部分CHF患者服用西洛他唑,并描述其安全性。我们将讨论对幼年特发性关节炎患者过敏性条件与慢性葡萄膜炎之间关系的临床假设的检验。
课程简介: In the era of EHRs, it is possible to examine the outcomes of decisions made by doctors during clinical practice to identify patterns of care—generating evidence based on the collective practice of experts. We will discuss methods that use unstructured patient data to monitor for adverse drug events, profile specific drugs, identify off-label drug usage, uncover ‘natural experiments’ and generate practice-based evidence for difficult-to-test clinical hypotheses. We will describe how to detect associations among drugs and their adverse events several years before an alert is issued as well as compute the true rate of drug-drug interactions. We will present approaches to identify novel off-label uses of drugs using the patient feature matrix along with prior knowledge about drugs, diseases, and known usage. We will review a natural experiment—where a subset of CHF patients who were prescribed Cilostazol despite its black box warning—and profile its safety. We will discuss the testing of a clinical hypothesis about an association between allergic conditions and chronic uveitis in patients with juvenile idiopathic arthritis.
关 键 词: 临床实践; 护理模式; 自然实验
课程来源: 视频讲座网
数据采集: 2022-11-29:chenjy
最后编审: 2022-11-29:chenjy
阅读次数: 19