图 书 馆
聚类和分类的细菌软地形图Soft Topographic Map for Clustering and Classification of Bacteria |
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| 课程网址: | http://videolectures.net/ida07_la_rosa_stm/ |
| 主讲教师: | Massimo La Rosa |
| 开课单位: | 国家研究委员会 |
| 开课时间: | 2007-10-08 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | In this work a new method for clustering and building a topographic representation of a bacteria taxonomy is presented. The method is based on the analysis of stable parts of the genome, the so-called “housekeeping genes”. The proposed method generates topographic maps of the bacteria taxonomy, where relations among different type strains can be visually inspected and verified. Two well known DNA alignement algorithms are applied to the genomic sequences. Topographic maps are optimized to represent the similarity among the sequences according to their evolutionary distances. The experimental analysis is carried out on 147 type strains of the Gammaprotebacteria class by means of the 16S rRNA housekeeping gene. Complete sequences of the gene have been retrieved from the NCBI public database. In the experimental tests the maps show clusters of homologous type strains and presents some singular cases potentially due to incorrect classification or erroneous annotations in the database. |
| 关 键 词: | 细菌分类; DNA定位算法应用; 基因的完整序列 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2020-10-14：yumf |
| 阅读次数: | 51 |