0


整合生物数据的核方法

Kernel methods for integrating biological data
课程网址: http://videolectures.net/prib2010_deridder_kmi/  
主讲教师: Dick de Ridder
开课单位: 代尔夫特理工大学
开课时间: 2010-10-14
课程语种: 英语
中文简介:
综合生物信息学专注于构建生物现象的近似模型,如基因调控,蛋白质相互作用和复合物形成,或蛋白质功能。这些模型基于丰富的先验知识(数据库,文献)和可用的高通量测量数据。一个主要的挑战是如何结合这些不同的信息来源,这些信息来源通常在数据类型,偏见,覆盖范围等方面存在差异。在过去十年中,越来越多地采用内核方法来解决这些问题。内核可用于许多算法,包括分类和回归(支持向量机),降维和统计。现在可以获得专门为某些类型的(生物)数据定制的大量内核,并且已经提出了各种方法来组合内核。在本教程中,我们将介绍基于内核的预测算法,讨论与生物建模相关的许多内核以及集成各种内核进行预测的方法。最后,我们将讨论核组合在生物问题中的一些应用。
课程简介: Integrative bioinformatics focuses on the construction of approximate models of biological phenomena, such as gene regulation, protein interaction and complex formation, or protein function. Such models are based on a wealth of prior knowledge (databases, literature) and high-throughput measurement data available. A major challenge is how to combine these various sources of information, which often differ in data type, bias, coverage etc. Over the last decade, kernel methods have been increasingly employed to tackle such problems. Kernels can be used in many algorithms, including classification and regression (the support vector machine), dimensionality reduction and statistics. A large number of kernels specifically tailored for certain types of (biological) data are now available, and various methods have been proposed to combine kernels. In this tutorial, we will introduce kernel-based predictive algorithms, discuss a number of kernels relevant to biological modeling and methods to integrate various kernels for prediction. We will end by discussing some applications of kernel combination to biological problems.
关 键 词: 计算机科学; 机器学习; 核方法
课程来源: 视频讲座网
最后编审: 2020-06-18:dingaq
阅读次数: 42