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7.340再生医学:从替补到床边(麻省理工学院

7.340 Regenerative Medicine: from Bench to Bedside (MIT)
课程网址: http://ocw.mit.edu/courses/biology/7-340-regenerative-medicine-fr...  
主讲教师: Simic, Petra
开课单位: 麻省理工学院
开课时间: 2010-01-01
课程语种: 英语
中文简介:
再生医学涉及用于治疗目的的组织的修复和再生,例如在心脏病发作后替换白血病中的骨髓,骨关节炎中的软骨或心脏细胞。在本课程中,我们将探索细胞如何分化成特定组织以响应各种生物信号分子的基本机制。我们将讨论这些因子在体外组织生产中的用途。我们还将研究与动物克隆有关的细胞机制以及苏格兰研究人员如何使用成年绵羊乳腺细胞核制作绵羊多莉。我们将阅读描述器官生成的论文,例如心脏跳动细胞的体外形成。我们还将考虑细胞组织重塑的分子基础来纠正这些变化。我们将讨论再生的发育,细胞和分子生物学的研究如何导致新药的发现。本课程是麻省理工学院生物系提供的许多高级本科研讨会之一。这些研讨会专为有兴趣使用初级研究文献的学生量身定制,以便在高度互动的环境中讨论和了解当前的生物学研究。高级本科生研讨会的许多讲师都是博士后科学家,他们对教学非常感兴趣。
课程简介: Regenerative medicine involves the repair and regeneration of tissues for therapeutic purposes, such as replacing bone marrow in leukemia, cartilage in osteoarthritis or cells of the heart after a heart attack. In this course, we will explore basic mechanisms of how cells differentiate into specific tissues in response to a variety of biologic signaling molecules. We will discuss the use of such factors for in vitro tissue production. We will also study the cellular mechanisms involved in the cloning of animals and how Scottish researchers produced the sheep Dolly using the nucleus of a mammary gland cell from an adult sheep. We will read papers describing organ production, such as the in vitro formation of beating heart cells. We will also consider the molecular bases of cellular tissue remodeling to correct these changes. We will discuss how studies of the developmental, cellular and molecular biology of regeneration have led to the discovery of new drugs. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
关 键 词: 再生医学; 组织修复; 细胞分化; 干细胞
课程来源: 麻省理工学院公开课
最后编审: 2015-11-30:linxl
阅读次数: 44