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学习和记忆:在神经系统的活动控制的基因表达

Learning and Memory: Activity-Controlled Gene Expression in the Nervous System
课程网址: http://ocw.mit.edu/courses/biology/7-340-learning-and-memory-acti...  
主讲教师: Sven Loebrich
开课单位: 麻省理工学院
开课时间: 2009-01-01
课程语种: 英语
中文简介:
哺乳动物的大脑很容易胜过任何计算机。它不断适应和变化。最重要的是,大脑使我们能够不断学习和记忆。导致学习和记忆的分子机制是什么?活动调节基因产物在实现大脑变化方面发挥的细胞作用是什么?神经细胞,它们的连接(突触)和大脑回路如何随时间变化来存储信息?我们将讨论神经元可塑性在突触,细胞和回路水平的分子机制,特别是突触形成,突触生长和稳定,突触传递,轴突和树突生长,以及电路形成我们将了解一些活动调节基因的作用以及现代神经科学中使用的工具和技术。我们的目标是了解大脑用于完成学习和记忆的分子机制。本课程是麻省理工学院生物系提供的许多高级本科研讨会之一。这些研讨会专为有兴趣使用初级研究文献的学生量身定制,以便在高度互动的环境中讨论和了解当前的生物学研究。高级本科生研讨会的许多讲师都是博士后科学家,他们对教学非常感兴趣。
课程简介: The mammalian brain easily outperforms any computer. It adapts and changes constantly. Most importantly, the brain enables us to continuously learn and remember. What are the molecular mechanisms that lead to learning and memory? What are the cellular roles that activity-regulated gene products play to implement changes in the brain?How do nerve cells, their connections (synapses), and brain circuits change over time to store information? We will discuss the molecular mechanisms of neuronal plasticity at the synaptic, cellular and circuit levels, especiallysynapse formation,synaptic growth and stabilization,synaptic transmission,axonal and dendritic outgrowth, andcircuit formationWe will learn about the roles of some activity-regulated genes as well as the tools and techniques employed in modern neuroscience. Our goal will be to understand molecular mechanisms the brain employs to accomplish learning and memory.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
关 键 词: 哺乳动物大脑细胞; 神经细胞; 突触
课程来源: 麻省理工学院公开课
最后编审: 2020-10-21:yumf
阅读次数: 35