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7.342 Cancer Biology: From Basic Research to the Clinic (MIT)

7.342 Cancer Biology: From Basic Research to the Clinic (MIT)
课程网址: http://ocw.mit.edu/courses/biology/7-342-cancer-biology-from-basi...  
主讲教师: Dr. Carla Kim; Dr. Kevin Haigis
开课单位: 麻省理工学院
开课时间: 2004-10-01
课程语种: 英语
中文简介:
本课程是麻省理工学院生物系提供的众多高级本科研讨会之一。这些研讨会专为有兴趣使用初级研究文献的学生量身定制,以便在高度互动的环境中讨论和了解当前的生物学研究。 1971年,尼克松总统宣布了“对抗癌症的战争”,但三十年后,战争仍在肆虐。我们在赢得战争方面取得了多大进展,我们正在做些什么来改善战斗?了解肿瘤形成,进展和转移中涉及的分子和细胞事件对于癌症患者创新疗法的开发至关重要。通过在酵母,线虫,小鼠和细胞培养模型中使用生物化学,分子和遗传分析的基础研究,已经对这些过程进行了深入了解。我们将探索用于进行癌症研究的实验室工具和技术,癌症生物学的主要发现以及这些突破的医学意义。本课程的重点是对主要文献进行批判性分析,以促进对各种癌症研究方法的优势和局限性的理解。将特别关注在模式生物中进行的癌症研究的临床意义以及结束与这种破坏性疾病的战斗的前景。
课程简介: This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. In 1971, President Nixon declared the "War on Cancer," but after three decades the war is still raging. How much progress have we made toward winning the war and what are we doing to improve the fight? Understanding the molecular and cellular events involved in tumor formation, progression, and metastasis is crucial to the development of innovative therapy for cancer patients. Insights into these processes have been gleaned through basic research using biochemical, molecular, and genetic analysis in yeast, C. elegans, mice, and cell culture models. We will explore the laboratory tools and techniques used to perform cancer research, major discoveries in cancer biology, and the medical implications of these breakthroughs. A focus of the class will be critical analysis of the primary literature to foster understanding of the strengths and limitations of various approaches to cancer research. Special attention will be made to the clinical implications of cancer research performed in model organisms and the prospects for ending the battle with this devastating disease.
关 键 词: 生物学研究; 癌症研究; 文献
课程来源: 麻省理工学院公开课
最后编审: 2021-10-04:nkq
阅读次数: 52