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大原则：在人类疾病中的作用的线粒体
Powerhouse Rules: The Role of Mitochondria in Human Diseases |
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| 课程网址: |
http://ocw.mit.edu/courses/biology/7-342-powerhouse-rules-the-rol...
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| 主讲教师: |
Ferullo Daniel
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| 开课单位: |
麻省理工学院
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| 开课时间: |
2011-01-01
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| 课程语种: |
英语
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| 中文简介: |
线粒体的主要作用是通过称为氧化磷酸化的过程以ATP的形式产生90％的细胞能量。已经显示多种临床病症包括“线粒体功能障碍”，松散地指氧化磷酸化缺陷并且通常与过量活性氧（ROS）产生的发生一致，将细胞置于氧化应激下。氧化应激的已知原因和结果是线粒体DNA的损伤和突变。我们将使用该课程来探索与线粒体DNA完整性及其在人类疾病中如何被损坏，修复，突变和妥协相关的问题。本课程是麻省理工学院生物系提供的许多高级本科研讨会之一。这些研讨会专为有兴趣使用初级研究文献的学生量身定制，以便在高度互动的环境中讨论和了解当前的生物学研究。高级本科生研讨会的许多讲师都是博士后科学家，他们对教学非常感兴趣。
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| 课程简介: |
The primary role of mitochondria is to produce 90% of a cell's energy in the form of ATP through a process called oxidative phosphorylation. A variety of clinical disorders have been shown to include "mitochondrial dysfunction," which loosely refers to defective oxidative phosphorylation and usually coincides with the occurrence of excess Reactive Oxygen Species (ROS) production, placing cells under oxidative stress. A known cause and effect of oxidative stress is damage to and mutation of mitochondrial DNA. We will use this class to explore issues relating to mitochondrial DNA integrity and how it can be damaged, repaired, mutated, and compromised in human diseases. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
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| 关 键 词: |
人类疾病; 线粒体; ATP; 氧化磷酸化; 线粒体基因组
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| 课程来源: |
麻省理工学院公开课
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| 最后编审: |
2020-10-21：yumf
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| 阅读次数: |
43
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