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肿瘤抑制基因:如何预防癌症基因组的守护者

Tumor Suppressor Gene p53: How the Guardian of our Genome Prevents Cancer
课程网址: http://ocw.mit.edu/courses/biology/7-344-tumor-suppressor-gene-p5...  
主讲教师: Wen Xue
开课单位: 麻省理工学院
开课时间: 2010-01-01
课程语种: 英语
中文简介:
癌症是全球死亡的主要原因。癌症涉及不受控制的细胞生长,对细胞死亡的抗性,不能分化成特定细胞类型,以及增加的细胞运动性。被称为肿瘤抑制基因的一系列门卫基因在预防癌症的发生和发展中起重要作用。其中,p53最为着名。由于其在维持基因组完整性中的重要作用,p53通常被称为基因组的守护者。在本课程中,我们将研究p53如何作为预防癌症的关键肿瘤抑制基因。本课程是麻省理工学院生物系提供的许多高级本科研讨会之一。这些研讨会专为有兴趣使用初级研究文献的学生量身定制,以便在高度互动的环境中讨论和了解当前的生物学研究。高级本科生研讨会的许多讲师都是博士后科学家,他们对教学非常感兴趣。
课程简介: Cancer is a leading cause of death worldwide. Cancer involves uncontrolled cell growth, resistance to cell death, failure to differentiate into a particular cell type, and increased cellular motility. A family of gate-keeper genes, known as tumor suppressor genes, plays important roles in preventing the initiation and progression of cancer. Among these, p53 is the most famous. Because of its essential role in maintaining genomic integrity, p53 is often called the guardian of the genome. During this course, we will study how p53 serves as a pivotal tumor suppressor gene in preventing cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
关 键 词: 癌症; 细胞生长失控; 抗细胞死亡; 肿瘤抑制基因
课程来源: 麻省理工学院公开课
最后编审: 2020-10-21:yumf
阅读次数: 54