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突触可塑性和记忆，从分子到行为
Synaptic Plasticity and Memory, from Molecules to Behavior |
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| 课程网址: |
http://ocw.mit.edu/courses/biology/7-346-synaptic-plasticity-and-...
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| 主讲教师: |
Dr. Ariel Kamsler
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| 开课单位: |
麻省理工学院
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| 开课时间: |
2007-01-01
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| 课程语种: |
英语
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| 中文简介: |
在本课程中, 我们将发现创新技术与深刻的假设相结合是如何引起我们目前对神经科学的理解的。我们将研究新的和经典的主要研究论文, 重点是大脑结构中突触之间的可塑性, 这被认为是创造和检索某些类型记忆的能力的基础。我们将讨论神经元的基本电特性以及它们是如何发射的。我们将看到燃烧特性如何随着经验的变化而变化, 我们将研究这些变化的生化基础。我们将学习分子生物学如何被用来专门改变大脑回路的生化特性, 我们将看到这些电路是如何形成空间的表示, 从而在活体动物中产生复杂的行为。将特别强调了解为什么要做具体的实验, 以及如何设计实验来回答你对大脑的问题。本课程是麻省理工学院生物系提供的众多高级本科生研讨会之一。这些研讨会是为有兴趣利用初级研究文献在高度互动的环境中讨论和了解当前生物研究的学生量身定制的。高级本科生研讨会的许多教员都是对教学有浓厚兴趣的博士后科学家。
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| 课程简介: |
In this course we will discover how innovative technologies combined with profound hypotheses have given rise to our current understanding of neuroscience. We will study both new and classical primary research papers with a focus on the plasticity between synapses in a brain structure called the hippocampus, which is believed to underlie the ability to create and retrieve certain classes of memories. We will discuss the basic electrical properties of neurons and how they fire. We will see how firing properties can change with experience, and we will study the biochemical basis of these changes. We will learn how molecular biology can be used to specifically change the biochemical properties of brain circuits, and we will see how these circuits form a representation of space giving rise to complex behaviors in living animals. A special emphasis will be given to understanding why specific experiments were done and how to design experiments that will answer the questions you have about the brain. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
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| 关 键 词: |
突触可塑性; 神经回路; 网格单元; 恐惧备忘录
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| 课程来源: |
麻省理工学院公开课
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| 最后编审: |
2016-03-20：gmj
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| 阅读次数: |
45
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