图 书 馆
用生物意识的隐含狄利克雷分布来表示微阵列的分类Biologically-aware Latent Dirichlet Allocation (BaLDA) for the Classification of Expression Microarray |
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| 课程网址: | http://videolectures.net/prib2010_bicego_blda/ |
| 主讲教师: | Manuele Bicego |
| 开课单位: | 维罗纳大学 |
| 开课时间: | 2010-10-14 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Topic models have recently shown to be really useful tools for the analysis of microarray experiments. In particular they have been successfully applied to gene clustering and, very recently, also to samples classification. In this latter case, nevertheless, the basic assumption of functional independence between genes is limiting, since many other a priori information about genes’ interactions may be available (co-regulation, spatial proximity or other a priori knowledge). In this paper a novel topic model is proposed, which enriches and extends the Latent Dirichlet Allocation (LDA) model by integrating such dependencies, encoded in a categorization of genes. The proposed topic model is used to derive a highly informative and discriminant representation for microarray experiments. Its usefulness, in comparison with standard topic models, has been demonstrated in two different classification tests. |
| 关 键 词: | 微阵列实验; 基因聚类; 隐含狄利克雷分配 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2020-06-03：毛岱琦(课程编辑志愿者) |
| 阅读次数: | 49 |