图 书 馆
短期突触促进维持活动记忆Active memory maintenance with short-term synaptic facilitatio |
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| 课程网址: | http://videolectures.net/eccs08_mongillo_ammwstsf/ |
| 主讲教师: | Gianluigi Mongillo |
| 开课单位: | 勒内·笛卡尔大学 |
| 开课时间: | 2008-10-17 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Current theoretical framework holds that information is actively maintained in working memory through enhanced firing rates (delay activity). This would be achieved either via persistent activity reverberation within selective neural populations or as a result of intrinsic single-cell properties (i.e. bi-stability). Electrophysiological studies show, however, that delay activity increase can be modest, sometimes completely disappearing during part of the delay period. We therefore propose a new theoretical framework whereby working memory is sustained by calcium-mediated synaptic facilitation in the recurrent connections of neocortical networks. In this account, the presynaptic residual calcium is used as a 'buffer' which is loaded, refreshed and read-out by spiking activity. Due to the long time constants of calcium kinetics, the refresh rate can be very low, which results in a mechanism that is metabolically efficient and resistant to external interferences. The duration and stability of working memory can be effectively regulated by modulating the spontaneous activity in the network. Joint work with: Omri Barak and Misha Tsodyks |
| 关 键 词: | 选择性神经群体; 延迟活动; 突触 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-03-20：lxf |
| 阅读次数: | 78 |