图 书 馆
果蝇基因表达模式的稀疏特征及术语间相互作用Drosophila Gene Expression Pattern Annotation Using Sparse Features and Term-term Interactions |
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| 课程网址: | http://videolectures.net/kdd09_ye_dgepausftti/ |
| 主讲教师: | Jieping Ye |
| 开课单位: | 密歇根大学 |
| 开课时间: | 2009-09-14 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | The Drosophila gene expression pattern images document the spatial and temporal dynamics of gene expression and they are valuable tools for explicating the gene functions, interaction, and networks during Drosophila embryogenesis. To provide text-based pattern searching, the images in the Berkeley Drosophila Genome Project (BDGP) study are annotated with ontology terms manually by human curators. We present a systematic approach for automating this task, because the number of images needing text descriptions is now rapidly increasing. We consider both improved feature representation and novel learning formulation to boost the annotation performance. For feature representation, we adapt the bag-of-words scheme commonly used in visual recognition problems so that the image group information in the BDGP study is retained. Moreover, images from multiple views can be integrated naturally in this representation. To reduce the quantization error caused by the bag-of-words representation, we propose an improved feature representation scheme based on the sparse learning technique. In the design of learning formulation, we propose a local regularization framework that can incorporate the correlations among terms explicitly. We further show that the resulting optimization problem admits an analytical solution. Experimental results show that the representation based on sparse learning outperforms the bag-of-words representation significantly. Results also show that incorporation of the term-term correlations improves the annotation performance consistently. |
| 关 键 词: | 果蝇基因; 基因表达; 基因组计划 |
| 课程来源: | 视频讲座网 |
| 最后编审: | 2019-05-10：lxf |
| 阅读次数: | 72 |