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主题演讲:学术视角

Keynote Presentation: Academic Perspectives
课程网址: http://videolectures.net/mitworld_hood_kp/  
主讲教师: Leroy Hood
开课单位: 系统生物学研究所
开课时间: 2013-02-04
课程语种: 英语
中文简介:
非常简单地说,系统生物学试图“捕捉生命系统的动态本质。”为了实现这一点,胡德说,你“必须将生物学,化学,计算机科学,工程和物理学的风格融合在一起”等等。这是一个需要解决的广阔领域。但是,借助互联网和数字DNA以及蛋白质测序仪等工具,现在可以进行旨在揭示简单生物体中基因和环境的复杂相互作用的研究。 胡德描述了敲除酵母细胞基因,并关闭代谢单糖的机器。这种微观篡改使科学家们能够建立日益复杂的模型。海胆中基因调控的蓝图帮助一位科学家找到了用两种胆量重新设计生物体的方法。但最终的奖项是对人类生物学的深刻理解。胡德预计在纳米技术的帮助下建立一个数据库 - 对人类基因组中的所有蛋白质进行分类和量化。科学家将能够通过检测血液样本中的缺陷基因来预测疾病,然后操纵基因来预防疾病。 “生物学和医学的整合,”胡德说,“橡胶与道路相遇。”
课程简介: Very simply stated, systems biology attempts to “capture the dynamic nature of living systems.” To accomplish this, says Hood, you “have to bring together the flavors of biology, chemistry, computer science, engineering and physics,” among others. It’s a vast area to tackle. But with tools like the internet and digital DNA and protein sequencers on hand, it’s now possible to perform research aimed at unraveling the complex interaction of genes and environment in simple organisms. Hood describes knocking out yeast cell genes, and turning off the machinery that metabolizes simple sugars. This sort of microscopic tampering allows scientists to build models of increasing complexity. A blueprint of gene regulation in sea urchins helped one scientist figure out a way to redesign the organism with two guts. But the ultimate prize is a deep understanding of human biology. Hood foresees a database—built with the help of nanotechnology — that categorizes and quantifies all proteins in the human genome. Scientists will be able to predict disease by detecting defective genes in blood samples, and then manipulate the genes to prevent the disease. “The integration of biology and medicine,” says Hood, “is where the rubber meets the road.”
关 键 词: 系统生物学; 蛋白质测序; 人类生物学
课程来源: 视频讲座网
最后编审: 2019-06-03:cjy
阅读次数: 31