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淀粉样蛋白形成蛋白/肽的相互陪伴Mutual chaperoning by amyloid forming proteins/peptides |
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| 课程网址: | http://videolectures.net/snc2015_zerovnik_mutual_chaperoning/ |
| 主讲教师: | Eva Žerovnik |
| 开课单位: | 约瑟夫·斯特凡研究所 |
| 开课时间: | 2015-10-01 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | We study the mechanisms of protein aggregation and cellular toxicity by the prefibrillar oligomers formed intracellularly by amyloidogenic proteins and some of their pathological mutants. It is an accepted view that the most toxic are soluble oligomers in range of 6 to 30 mers, that are membrane seeking and even make pores into membranes (1-2). I will discuss the proposal that changed pre-amyloidogenic conformations of amyloid forming proteins may act as mutual chaperones, leading to temporary inhibition of aggregation and toxicity. Examples will be described of crystallins, prion protein and stefin B; all binders of amyloid-beta (3). Small molecule inhibitors of protein aggregation will also be discussed. Our main model protein from the family of cystatins, stefin B will be described in more detail. It’s possible function in the cell’s response to protein mis-folding will be high-lighted (4). |
| 关 键 词: | 淀粉样蛋白; 蛋白质聚集; 可溶性低聚物 |
| 课程来源: | 视频讲座网 |
| 数据采集: | 2022-02-20：zkj |
| 最后编审: | 2022-02-23：liyy |
| 阅读次数: | 57 |