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药物开发过程：对抗疼痛Drug development process: combating pain |
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| 课程网址: | https://www.open.edu/openlearn/science-maths-technology/science/d... |
| 主讲教师: | 信息不详。欢迎您在右侧留言补充。 |
| 开课单位: | 英国开放大学 |
| 开课时间: | 2012-10-05 |
| 课程语种: | 英语 |
| 中文简介: |  |
| 课程简介: | Drug discovery, from concept to clinic, is a complex and expensive process involving the work of an escalating number of people and resources over many years. A major component of this cost has been the attrition rate of medicines that reach the development stage but then fail as the result of adverse toxicity or only limited effectiveness against the target disease. In recent years much greater attention has been paid to addressing the problems of attrition at an earlier stage in the discovery process and moving the focus of research away from a strategy based purely on potency against the isolated target protein. It begins with practical, multidisciplinary, laboratory work leading to the identification of candidate molecules that are evaluated in large multinational clinical trials. The escalating costs are mirrored by the increasing demand for supply of the compound as development work proceeds. Typically, a hit is identified from a few milligrams of compound; preliminary pharmacokinetic and efficacy determination will typically require hundreds of milligrams to grams of material, escalating to perhaps kilograms for preclinical safety and pharmacy evaluation. By the time human trials are initiated, tens to hundreds of kilograms are often necessary; production may entail quantities measured in tonnes. This OpenLearn course is an adapted extract from the Open University course S827 Concept to clinic. |
| 关 键 词: | 药物开发; 对抗疼痛; 药物损耗率; 药学评估 |
| 课程来源: | 英国开放大学 |
| 数据采集: | 2022-05-05：tongdan |
| 最后编审: | 2022-05-05：tongdan |
| 阅读次数: | 31 |