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一把双刃剑:健康和疾病中的细胞免疫

A Double-Edged Sword: Cellular Immunity In Health And Disease
课程网址: https://ocw.mit.edu/courses/7-342-a-double-edged-sword-cellular-i...  
主讲教师: Dr. Haiting Ma
开课单位: 麻省理工学院
开课时间: 2018-01-01
课程语种: 英语
中文简介:
免疫细胞保护我们的身体免受自身威胁和外源性病原体的侵害,同时与正常细胞和无害的共生微生物群保持和平。它们有各种机制来执行这些任务,这种能力对于维持体内平衡至关重要。然而,这些相同的机制可能会适得其反,导致严重的疾病,如免疫缺陷、慢性炎症、过敏、退行性疾病和癌症。本课程通过研究先天性和适应性免疫细胞之间的发育关系以及免疫细胞的功能和功能障碍,讨论正常生理机能与疾病之间的联系。该课程使学生熟悉基本的生物学原理(如细胞死亡和免疫细胞信号传导)和临床应用(如免疫检查点阻断)。更一般地说,学生学习识别相关的原始研究文献,批判性地评估实验数据,并根据原始数据得出自己的结论。 本课程是麻省理工学院生物系提供的众多高级本科研讨会之一。这些研讨会是为有兴趣使用主要研究文献在高度互动的环境中讨论和了解当前生物学研究的学生量身定制的。高级本科生研讨会的许多讲师都是对教学有浓厚兴趣的博士后科学家。
课程简介: Course Description Immune cells protect our bodies from both self-derived threats and exogenous pathogens, while keeping peace with normal cells and non-harmful commensal microbiota. They have various mechanisms to perform these tasks, a capacity that is essential for maintaining homeostasis. However, these same mechanisms can backfire, resulting in severe disorders such as immunodeficiency, chronic inflammation, allergy, degenerative diseases, and cancer. This course discusses the connections between normal physiology and disease by examining the developmental relationship between innate and adaptive immune cells as well as the functions and malfunctions of immune cells. The course familiarizes students with both basic biological principles (such as cell death and immune cell signaling) and clinical applications (such as immune checkpoint blockade). More generally, students learn to identify relevant primary research literature, critically evaluate experimental data, and reach their own conclusions based on primary data. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
关 键 词: 细胞免疫; 自身威胁; 外源性病原体
课程来源: 麻省理工学院公开课
数据采集: 2024-02-18:chenjy
最后编审: 2024-02-18:chenjy
阅读次数: 5